While most Genesis, Sega CD and 32X games only required a standard 3-button controller, some can take advantage of additional accessories such as the 6-button controller, Sega/Mega Mouse and light guns. Some Sega CD games are also capable of saving directly to a battery-backed RAM cartridge, which is useful for some games as the Sega CD's own internal save memory is very small by comparison.
| Game Name | Game Type | Mouse Support | 6-Button Support | RAM Cart Support | Notes |
|---|---|---|---|---|---|
| After Burner | 32X | Also compatible with the XE-1AP controller | |||
| After Burner III | CD | Also compatible with the XE-1AP controller | |||
| Art of Fighting | Cartridge | ||||
| Battlecorps | CD | ||||
| Batman Forever | Cartridge | ||||
| Beyond Oasis | Cartridge | ||||
| BC Racers | CD and 32X | Released on both the Sega CD and 32X | |||
| Blackthorne | 32X | ||||
| Body Count | Cartridge | Also compatible with the Menacer light gun | |||
| Boogerman: A Pick and Flick Adventure | Cartridge | ||||
| Brutal: Paws of Fury | Cartridge and CD | Released on both cartridge and CD | |||
| Brutal Unleashed: Above the Claw | 32X | ||||
| Bubba 'n' Stix | Cartridge | ||||
| Cannon Fodder | Cartridge | ||||
| Chou Kyuukai Miracle Nine | Cartridge | ||||
| ClayFighter | Cartridge | ||||
| College Football's National Championship | Cartridge | ||||
| College Football's National Championship II | Cartridge | ||||
| Comix Zone | Cartridge | ||||
| Contra: Hard Corps/Probotector | Cartridge | ||||
| Cosmic Carnage | 32X | ||||
| Crime Patrol | CD | Also compatible with the GameGun, Konami Justifier and Menacer light guns | |||
| Darius Extra Version | Cartridge | ||||
| Darxide | 32X | ||||
| Davis Cup Tennis | Cartridge | ||||
| Desert Demolition Starring Road Runner and Wile E. Coyote | Cartridge | ||||
| Doom | 32X | ||||
| Double Dragon V: The Shadow Falls | Cartridge | ||||
| Dragon: The Bruce Lee Story | Cartridge | ||||
| Dragon Ball Z: Buyuu Retsuden | Cartridge | ||||
| Duke Nukem 3D | Cartridge | ||||
| Dungeon Master II: Skullkeep | CD | ||||
| Dyna Brothers 2 | Cartridge | ||||
| Eternal Champions | Cartridge | ||||
| Eternal Champions: Challenge From the Dark Side | CD | ||||
| Eye of the Beholder | CD | ||||
| Fatal Fury | Cartridge | ||||
| Fatal Fury 2 | Cartridge | ||||
| Fever Pitch Soccer | Cartridge | ||||
| Fun 'n' Games | Cartridge | ||||
| Garfield: Caught in the Act | Cartridge | ||||
| Greatest Heavyweights | Cartridge | ||||
| Iron Helix | CD | ||||
| Instruments of Chaos Starring Young Indiana Jones | Cartridge | ||||
| International Superstar Soccer Deluxe | Cartridge | ||||
| Janou Touryuumon | Cartridge | ||||
| Jimmy White's Whirlwind Snooker | Cartridge | ||||
| Judge Dredd | Cartridge | ||||
| Justice League Task Force | Cartridge | ||||
| Lemmings 2: The Tribes | Cartridge | ||||
| Links: The Challenge of Golf | CD | Also compatible with the TeeV Golf accessory | |||
| The Lion King | Cartridge | ||||
| Loadstar: The Legend of Tully Bodine | CD | ||||
| Lord Monarch | Cartridge | ||||
| The Lost Vikings | Cartridge | ||||
| Mad Dog McCree | CD | Also compatible with the GameGun, Konami Justifier and Menacer light guns | |||
| Mad Dog II: The Lost Gold | CD | Also compatible with the GameGun, Konami Justifier and Menacer light guns | |||
| Marble Madness (Tengen) | Cartridge | Japan-only release, the earlier Electronic Arts version is only compatible with a standard controller | |||
| Mega Turrican | Cartridge | ||||
| Metal Head | 32X | ||||
| MiG-29 Fighter Pilot | Cartridge | ||||
| Might and Magic III: Isles of Terra | CD | ||||
| Mortal Kombat | Cartridge | ||||
| Mortal Kombat II | Cartridge | ||||
| Mortal Kombat 3 | Cartridge | ||||
| My Paint | CD | ||||
| NBA Action '94 | Cartridge | ||||
| NBA Action '95 Starring David Robinson | Cartridge | ||||
| NFL '95 | Cartridge | ||||
| Nobunaga no Yabou: Haouden | Cartridge and CD | CD | On both cartridge and CD | ||
| Nobunaga's Ambition | Cartridge | ||||
| Panic!/Switch | CD | ||||
| Richard Scarry's Busytown | Cartridge | ||||
| The Secret of Monkey Island | CD | ||||
| Shadowrun | CD | ||||
| Shanghai II: Dragon's Eye | Cartridge | ||||
| Shin Megami Tensei | CD | ||||
| Shining Force CD | CD | Practically requires the RAM cart because the Sega CD's internal memory is not large enough to store every adventure. The final adventure (Book 4) is only accessible using a RAM cart | |||
| StarBlade | CD | Also supports the XE-1AP controller | |||
| Street Fighter II': Special Champion Edition | Cartridge | ||||
| Streets of Rage 3 | Cartridge | ||||
| Super Street Fighter II: The New Challengers | Cartridge | ||||
| Supreme Warrior | CD and CD 32X | Available as both a standard Sega CD and Sega CD 32X game | |||
| ToeJam & Earl in Panic on Funkotron | Cartridge | ||||
| True Lies | Cartridge | ||||
| Ultimate Mortal Kombat 3 | Cartridge | ||||
| Urban Strike | Cartridge | ||||
| Urusei Yatsura: Dear My Friends | CD | ||||
| Virtua Fighter | 32X | ||||
| Virtua Fighter 2 | Cartridge | ||||
| VR Troopers | Cartridge | ||||
| Wacky Worlds | Cartridge | ||||
| Warau Salesman | CD | ||||
| Weaponlord | Cartridge | ||||
| Who Shot Johnny Rock? | CD | Also compatible with the GameGun, Konami Justifier and Menacer light guns | |||
| Williams Arcade's Greatest Hits | Cartridge | ||||
| Wing Commander | CD | ||||
| World Heroes | Cartridge | ||||
| World Series Baseball '95 | Cartridge | ||||
| World Series Baseball '96 | Cartridge | ||||
| WWF Rage in the Cage | CD | ||||
| WWF WrestleMania: The Arcade Game | Cartridge and 32X | Released on both standard cartridge and 32X | |||
| Yumemi Mystery Mansion | CD | ||||
| Yuu Yuu Hakusho: Makyou Toitsusen | Cartridge |